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What is a Bufo ceremony? Understanding the sacred use of 5-MeO-DMT

by Daniel Hannah

Spiritual coach and student of ancestral medicine traditions. Since 2016, deeply immersed in plant medicine communities and spiritual practices across South America.

Last updated: March 26, 2026

The Wachumeros of the Andes say that Bufo prepares us for death, as it induces an experience so profound that not even the material world can remain. Although many powerful medicines exist in the shamanic healing space, nothing quite matches the intensity of Bufo Alvarius DMT: The God molecule.

Although Bufo is a more recent addition to ancestral medicines that have been steeped in tradition for thousands of years, it is quickly being adopted by shamanic healers all over the world due to its profound effects on consciousness.

In this article, we’re going to run through everything you need to know if you’re seeking out Bufo Alvarius, and clear up any doubts if you’re wondering: What is a Bufo ceremony?

What is Bufo Alvarius?

Bufo is a potent psychoactive medicine that comes from the venom of the Bufo Alvarius toad. Native to the Sonoran Desert region of Mexico and the Southwestern United States, Bufo (also known as the Colorado River Toad) is a semi-aquatic toad that spends much of the year burrowed underground, emerging during the rainy season to breed.

Rainy periods provide a window where the toad’s secretions are harvested for its naturally occurring 5-MeO-DMT, which you can learn more about here. The secretions of the toad are collected, dried, and then smoked to experience the effects of 5-MeO-DMT: A particularly powerful, but short-lasting form of DMT, not so different from N-N-DMT found in Ayahuasca.

The use of Bufo in shamanic settings has been gaining traction quickly since the late 1900s. Due to the profound effects of this molecule on consciousness, Bufo ceremonies have become increasingly incorporated into shamanic traditions all over the Americas.

While modern medicine communities have popularised the use of 5-MeO-DMT in ceremonies, it’s important to note that Bufo Alvarius is an ancient creature that lived on this land long before it was used ceremonially. The Yaqui (a native group from this region) has made it clear that the toad’s cultural importance comes from its symbolic role rather than its venom.

That said, we must honour and respect the animal. This toad is not just a vehicle for personal transformation, but it’s a living being that has a particular significance to the land, indigenous culture, and ecosystem. Therefore, it’s essential to work with Bufo only in places where it’s ethically sourced, and the animal is not harmed or exploited.

Communing with the spirit of Bufo

While it isn’t a traditional ancestral medicine like Kambó, Bufo Alvarius DMT is recognised as a spirit by practitioners, and is often described as one of the most powerful messengers of the divine. Unlike plant medicines that tend to unravel the ego over hours, leading to a more introspective journey into consciousness, Bufo is like a cannon that can blast you into non-dual awareness in moments.

The experience of dissolving into the source, God, and infinite frequency of love pulsating through the cosmos is generally considered a face-to-face encounter with the spirit of Bufo itself. Bufo might not talk to you like Ayahuasca does or be a guiding hand like San Pedro, but it will probably be the most profound encounter with truth you have had.

With that said, people often view Bufo Alvarius DMT as a tool to facilitate powerful spiritual experiences, including:

  • Ego death and a complete dissolution of self
  • Profound spiritual insights and realisations
  • Spiritual rebirth and a reset on all levels of consciousness
  • Direct connection with higher realms of existence
  • Deep emotional release and the act of letting go
  • Feelings of bliss, love, and divine connection

 

Bufo isn’t something to mess around with lightly. The experience can be extremely intense and disorientating, as within one moment your feet are firmly planted on the ground, and the next… reality doesn’t exist.

Anyone who isn’t accustomed to extraordinary states of consciousness induced through plant medicines may find the experience overwhelming. Therefore, this medicine must be treated with a huge level of respect and adequate preparation, and only used under the guidance of a trained healer. But for those hearing the call, you might still wonder: What is a Bufo ceremony like in practice?

 

Bufo ceremony. What to expect?

Every ancestral medicine is a teacher in some form. They each specialise in teaching different subjects, have various voices in which they speak to you, as well as a different classroom management style.

 

For example, Magic Mushrooms teach through play and creativity – they’re the art teacher in the shamanic schoolyard. Bufo is like the swimming teacher who drops the baby into the water and waits for him to float to the surface. His teaching methods might be controversial to some, but nobody can deny that he gets the job done.

 

Participating in a Bufo Alvarius ceremony is like working with a swimming teacher. He won’t hoist you gently into the cosmos… he will sweep the carpet out from under your feet and wait for you to resurface. It’s a full-immersion type of experience that catapults you out of your familiar constructs to experience something that can’t quite be described.

 

In particular, Bufo Alvarius DMT is a teacher of impermanence, surrender, non-resistance, and non-attachment. Due to the powerful, but short-lasting nature of the experience, this teacher gives us a quick glimpse of the divine unity that exists beyond the layers of materiality, mind, and emotion.

Therefore, in a Bufo ceremony, you can expect to have an encounter with the divine. This encounter with deeper levels of reality can facilitate great healing, introspection, and significant shifts in your perception and outlook on life.

 

How is the ceremony run?

Bufo has become popular over the last few decades among people who are seeking deep healing and transformation, not because they necessarily want to go on a wild trip, but because it makes us realise the temporariness of each experience of consciousness. In the blink of an eye, your experience is entirely foreign to what it once was, being a catalyst for all kinds of transformation.

But now that we’ve got the teaching style out of the way, what is a bufo ceremony, and how are they run? Bufo ceremonies are often conducted 1-1 or in a small group. The residue of the toad is smoked from a small pipe, one person at a time.

 

The shaman will generally bless the space and often sing ikaros, medicine music, or chant while the individual undergoes the experience. Music can be a grounding presence that keeps the person tethered to reality while warding off particular energies. However, a Bufo ceremony can also be done in silence. Silence is preferred by some people and potentially allows them to journey deeper into the medicine.

 

In some ways, ceremonies aren’t run so differently from ceremonies such as Kambó or Ayahuasca, although they tend to be shorter and more intimate. The purpose of the shaman is to act as the tether. Considering Bufo is an extremely potent medicine, the shaman energetically ties a cord to the person and keeps an eye on them while they venture into higher realms.

 

Often, there is a debriefing when all participants have remerged into reality, followed by a sharing circle and integration, and then closing of the ceremony.

 

Shaman performing a traditional Bufo Alvarius ceremony in a forest, with smoke rising and the Bufo toad present—capturing the sacred atmosphere of ancestral medicine as honoured in Avalon retreats at weareavalon.love.

Effects of Bufo Alvarius

The active ingredient in Bufo is 5-MeO-DMT. DMT (or Dymethyltryptamine) is a chemical component that exists in a plethora of living organisms, from plants and animals to even humans. 5-MeO-DMT is a similar spirit to DMT, but is generally considered to be more potent.

 

Ingesting Bufo Alvarius DMT leads to the almost-immediate dissolution, or death of the ego, allowing consciousness to temporarily free itself from the human container, creating a profound sense of connection with the universe and everything beyond.

 

The effects are immediate.

 

Without due mental and physical preparation, they can be overwhelming. The experience generally lasts no more than 30 minutes, peaking after a few minutes and then gradually dying down. However, the aftereffects can linger for weeks, often creating a glow of peace and calmness.

 

During a Bufo ceremony, common effects include:

  • Loss of identity, memories, and sense of self
  • Crystal clear 3d visuals (often abstract, geometrical, or fractal)
  • Auditory warping, humming sounds, and ringing
  • Time can appear to dissolve or not exist entirely
  • Abstract lights and patterns
  • The feeling of warmth washing over the body
  • Physical sensations such as warmth, tingling, and feelings of weightlessness
  • Feeling of rapid vibration and feeling of expansion
  • Feeling of merging into the visions

 

 

Generally, people lie down and surrender to the magnitude of the experience in a Bufo Alvarius ceremony, although the powerful experience can also elicit various reactions, including crying, yelling, laughing, trembling, and movement.

 

But don’t be concerned, these reactions are normal. In fact, emotional reactions to the experience can actually be cathartic as they act as a form of purge, or energetic release.

 

 

What’s the difference between Bufo and Kambó?

Many people tend to get confused with these two medicines, so let’s iron out the details. The medicines of Bufo and Kambó come from different animals, whose secretion is used for different purposes.

 

Bufo Alvarius is a toad that is native to the desert regions of North America (particularly North West Mexico and South West United States), although its use in the shamanic healing space is often referred to as a Bufo frog ceremony. Kambó is a type of frog that’s native to the Amazon basin and is particularly used by Indigenous healers of the Amazon, like the Huni Kuin, Noke Koi, and Yawanawá.

 

Bufo offers a powerful medicine journey that generally lasts for around 10 – 20 minutes, although the aftereffects can last for much longer. Kambó, on the other hand, doesn’t offer a spiritual journey in the same way that Bufo does, but rather acts as a powerful detox that cleans you physically, emotionally, and mentally.

 

Kambó is used as a purifier. When you take this medicine, the effects come on almost immediately, generally involving profuse sweating and flushing, redness and blushing of the skin, swelling of the face, and concomitant nausea that often leads to a purge. While people who use Kambó can have visions and insights, generally, the prominent effects are in the physical body.

 

 

Things to know before taking Bufo

Bufo is certainly not for everyone, as it is commonly known as one of the most powerful medicines known to mankind. How you show up for the medicine, physically, mentally, and emotionally, plays a significant role in how the experience will unfold.

 

Therefore, it’s important to heed the following advice if you’re thinking about participating in a Bufo frog ceremony:

 

  • Avoid if you have a history of mental illness, including schizophrenia, bipolar disorder, dissociative disorder, or psychosis: Bufo rapidly dissolves the ego, which can leave you with a fragile grip on reality. If you have any history with mental health disorders, the powerful experience can trigger episodes or worsen symptoms.
  • Avoid if you’re experiencing a recent trauma or instability: While some medicines can be beneficial in these situations, Bufo can completely destabilise you if you’re not in the right place emotionally to receive its teachings.
  • Avoid if you’re using certain medications: Similar to Ayahuasca, Bufo can clash with certain medications such as SSRIs. Before using Bufo, disclose any medications you use, including other plant medicines, to the healer.
  • Exercise caution when working with other plant medicines: There is no known historic use of mixing 5-MeO-DMT with other psychoactive plants, which could have unexpected or even deadly consequences. In our 6-day retreats, we wait for more than 24 hours after Ayahuasca to work with Bufo. This allows for adequate preparation and integration leading up to the Bufo ceremony.
  • Fast for 4-6 hours leading up to the experience: It’s important to have an empty stomach when working with Bufo. Although the medicine likely won’t make you purge, you don’t want to be digesting heavy food while Bufo is energetically wringing you out.
  • Eat clean and avoid impurities leading up to the Bufo Alvarius ceremony: As with other plant medicines, you want your body to be clean and light before working with Bufo. It’s best to avoid meat, sugar, alcohol, any other plant medicines, and anything that acts as an impurity to your body.

 

 

It is not recommended to try Bufo if you aren’t experienced with other plant medicines due to the extremely powerful experience that the medicine produces.

 

With that said, before working with Bufo Alvarius DMT, it’s best to:

 

  • Set intentions but not expectations
  • Ground yourself well before the ceremony
  • Mentally prepare yourself for the loss of self
  • Prepare yourself to let go and surrender to the experience

 

If you’re seeking out Bufo, keep in mind that it isn’t a recreational medicine. It’s a full-scale reset on all levels of being, and it’s not something you want to mess around with lightly.

 

The preparation process must be respected, as you should have the highest level of respect for the medicine while following the guidance of the healer facilitating the Bufo Alvarius ceremony. Likewise, it’s important to have an intention. Although the medicine of Bufo tends to show you what it wants, which may be abstract or overwhelming at first, your intentions act as your anchor and help direct the integration process.

 

Where to find Bufo?

There is a growing number of ancestral plant retreat centres now incorporating Bufo frog ceremonies into their retreats, and perceiving it as a valuable addition to the healing and transformation that guests often undergo during these retreats.

 

These retreats can be found particularly in the Sacred Valley of Peru due to the region’s large shamanic healing community. Sonora in Mexico (where the toad is found natively) is another hotspot, as well as Oaxaca, where Bufo is often used alongside Temazcales and other healing modalities such as breathwork and plant medicines.

 

Bufo Alvarius DMT has also made its way to countries such as Colombia, Costa Rica, Brazil, Portugal, and Spain. More medicine retreats around the world are incorporating the use of Bufo as a powerful tool for self-transformation and letting go.

 

At Avalon, we’ve found that Bufo can be a powerful complement to our medicine retreats and add a whole new level of depth to your journey. That’s why we’ve thoughtfully integrated this potent medicine into select retreats. If you feel the call to leave the ego behind and unite with the purity of consciousness we all share beyond the mask of separation, learn about our upcoming Bufo retreats here.

 

Bufo is not something you trip on, but rather something you surrender to. It can be heaven, it can be terrifying, and it can be everything at once. Regardless, most people will agree that participating in a Bufo Alvarius ceremony can change your life and expose you to a higher dimension of reality that many of us aren’t aware of.

 

Curious to know more? Book a discovery call with us and find out if this powerful journey is right for you.

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Meet the Author

Daniel Hannah

Archetype

Existence explorer. Voice of self-development. Nomad. Plant medicines supporter.

Role

Writer in residence.

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